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Can be tailored to different situations and lifestyles thanks to the different formats to manage physiological and situational cravings 24 Varenicline: Must stop smoking by the 5th day of treatment, and not smoke concurrently to avoid aggravating adverse reactions 18 Tablets should be discontinued in cases of treatment failure and can be resumed after 2-3 months 18 Cannot be used as needed when cravings occur Cytisine: Recommended to stop smoking after 1-2 weeks of starting 12 week course (abrupt quit) 19 Recommended to stop smoking by 12th week of starting 24 week course (reduce to quit) 19 Can be used for longer than 12 weeks if required 19 Cannot be used as needed when cravings occur Bupropion: Recommended to stop smoking within 2 weeks of 7-9 week course 20 If at 7 weeks no effect is seen, treatment should be discontinued 20 Cannot be used as needed when cravings occur To keep in mind: NRT offers: A management of cravings when they occur A reduce to quit option if they still smoke Tailored approaches to suit patient's lifestyles* Continued NRT usage in the event of relapse so patient can continue their quit journey *with the 7 formats How effective is pharmacotherapy

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Varenicline is the most effective of these treatments and has slightly higher efficacy compared with combination NRT

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