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doi: 10.1007/s10753-020-01219-8 107 SunXCuiYSuYGaoZDiaoXLiJet al

Recognizing these symptoms early allows for faster treatment and better outcomes

However, potential adverse drug effect, fragmented healthcare system and heavy economic burden all pose great challenges to patients long-term compliance, which largely weakens the effectiveness of drug therapy

It's worth noting that: Safety and regulation : Health authorities do not always control skin-lightening medications, raising concerns about their safety and potential negative effects

PMID: 15 LiJHuangQSunSZhouKWangXPanKet al

Intestinal barrier integrity and endotoxin translocation The intestinal barriercomprising the mucus layer, epithelial tight junctions, immune defenses, and chemical/biological shieldsprevents bacteria and toxins from entering the portal blood and reaching the liver