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This decline occurred despite a shift in the composition of youth vapers: as youth vaping declined after 2019, the remaining vapers are more likely to have signs of dependence (likely as the casual or experimental users stopped using and dropped out of the pool)

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Most of the studies (12 of 14) measured puffing topography in controlled environments, where puffing behavior may or may not represent e-cigarette use behavior in the real world. Two observational studies characterized puffing topography of experienced e-cigarette users of first-generation devices in their naturalistic environments

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