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"I am deeply sorry that I was wrong." Steadman's opening line was a last-minute improvisation, fuelled by Flying Dog Ale and Courvoisier, and replaced the introduction he'd prepared earlier

Bills paid, money in the bank, and breathing normally. Congratulations, and thank you for the inspiration, Dan

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Spontaneous rupture of large arteries was not observed at all and, in particular, neither in the 6 patients with the COL1A1 p.(Arg312Cys) missense variant nor in 2 individuals with different COL5A1 glycine substitutions at the C-terminal domain (Additional Table 1), which represent variants previously associated with a possible higher risk of vascular events [16]