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In the paracellular route, analytes traverse the inter-endothelial junctions (IEJs), which permit the passage of small molecules - generally molecules smaller than ~70 kDa - through diffusion and advection [44]

Nat Rev Neurol 14:606617

These factors could collectively impede the fertilization process (Lee et al., 2013)

doi:10.1073/pnas.87.9.3343 8

In human, Filipe et al

Oral Supplements: Why Delivery Route Matters Oral supplements must pass through the digestive system, where absorption is limited by gut health, transit time, supplement form, and interactions with food