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People whove never smoked develop signs of nicotine dependence when they start using e-cigarettes

Indeed, previously we reported suggestive evidence that there was a cross-over effect in the opposite direction with receptivity to e-cigarette advertising but not cigarette advertising associated with ever cigarette use in 2015 [42]

As mentioned earlier, federal prohibition has made research into the effects of cannabis largely observational, which can only detect correlation and not causation

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