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British American Tobacco In January 2000, the Guardian newspaper reported that British American Tobaccos (BAT) own documents revealed how the company had condoned tax evasion and exploited the smuggling of billions of cigarettes in a global effort to boost sales and lure generations of new smokers. Later the same year, BAT also faced serious racketeering charges in Columbia arising from its involvement in organised crime in pursuit of a massive, ongoing smuggling scheme. On July 15 2010, in an agreement between the European Commission and BAT the Tobacco Company paid US$200m to settle smuggling-related issues

Recent analysis of mutation spectra has also called into question the classic view that de novo mutations arise predominantly from replicative errors