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"So if your heart rate is 60 beats per minute, the subjects within two minutes will have a heart rate of 78 and sometimes 90." Sir Isi said he has also seen narrowed arteries in some long-term chewers and suspects betel nut use heightens the risk of heart attack

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Studies have shown that men who smoke tend to have a lower sperm count, poor sperm motility, and more abnormal-shaped sperm compared to non-smokers

Other significant contributors to his death included hypertension, hypothyroidism and hyperlipidemia, per the certificate