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Helicobacter pylori is a common bacterium that colonizes gastric mucosa and causes severe gastrointestinal issues in the gut (70)

1) Biomarker challenges: Classical ferroptosis markers (MDA, 4-HNE, and C11-BODIPY) are non-specific, as they are also generated by other oxidative stress pathways (e.g., ROS from mitochondrial dysfunction)

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Two defense-related genes, encoding a GST and a cytochrome P450, were regulated downstream of WRKY45, but were not regulated by NH1, suggesting independence of the WRKY45 and NH1 pathways (Shimono et al., 2007)

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These limitations have prompted increasing attention toward host-targeted therapeutic strategies, particularly interventions aimed at virus-induced PCD pathways (see the classification framework in Figure 4 and the specific agents in Table 3 )