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H.et al (2008)

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

It provides tumor cells sufficient energy and nutrients to adapt to various environmental stresses, including hypoxia and starvation, which are tightly linked to cell proliferation and survival

Delayed intervention may miss the optimal window for controlling inflammatory peaks, and treatment strategies should be adjusted according to individual tolerance