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Shaking the vial can shear these chains, rendering the compound useless

Proc Natl Acad Sci 106(2):381386 Kawahara M, Kato-Negishi M (2011) Link between aluminum and the pathogenesis of Alzheimer s disease: the integration of the aluminum and amyloid cascade hypotheses

doi: 10.1007/s00125-020-05180-x 6

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It is important to remember that IGF-I levels are generally naturally higher in children than in adults [24], which means that children need higher absolute IGF-I concentrations (ng/mL) than adults to achieve a desired therapeutic IGF-I SDS response