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Sublingual immunotherapy involves placing small doses of allergens under the tongue, gradually desensitizing the immune system to these triggers

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In addition, it discusses additional efficacy endpoints that may be used in NRT drug products that have already demonstrated effectiveness in smoking cessation or reduction of risk of relapse: reduction in urge to smoke, relief of cue-induced craving in former smokers, and relief of withdrawal symptoms not associated with a cessation attempt

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