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Alterations in the metabolic processes can lead to epigenetic and genetic perturbations, causative for diverse disorders, accelerated aging, and various age-related diseases

demonstrated that a single low-dose immunization with any of the three developed LNP-based herpes simplex virus type 1 glycoprotein D (gDE7) mRNA vaccines (self-amplifying mRNA, unmodified mRNA, and nucleoside-modified non-replicating mRNA vaccines) resulted in the activation of E7-specific CD8 + T cells, generated memory T cell responses to prevent tumor relapses, and destroyed cervical tumors (Ramos da Silva et al., 2023a)

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*Correspondence: Natalia Chyliska [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Since most osteoarthritis patients are elderly, treatment periods are prolonged due to patients extended lifetime

Accepted 2023-7-26