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This is probably due to another aspect of IGF-1 its binding proteins

then, TAU uptake was measured by liquid scintillation spectrometry

ferroptotic cells typically contain shrunken mitochondria with increased membrane density [53] and the main biochemical characteristics of ferroptosis consist of increased cellular labile iron, large amounts of ROS, decreased GPX4 activity, and accumulation of lipid metabolites [54]

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Based on this analysis, a nonparametric Kruskal-Wallis Analysis of Variance (ANOVA) was performed followed by a Dunnidk test for multiple comparisons (as implemented by Prism v7.0a, GraphPad Software