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Product dosing guides for monotherapy NicoDerm Patch* Step 1 | Weeks 1 6 For a heavy smoker: Use one 21 mg patch daily For a light smoker: Use one 14 mg patch daily Step 2 | Weeks 7 - 8 For a heavy smoker: Use one 14 mg patch daily For a light smoker: Use one 7 mg patch daily Step 3 | Weeks 9 - 10 For a heavy smoker: Use one 7 mg patch daily For a light smoker: If needed, continue using one 7 mg patch daily NICORETTE QuickMist Step 1 | Weeks 1 6 12 sprays every 3060 mins

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[59] [12] A pulmonary vascular COPD phenotype has been described involving cardiovascular dysfunction

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