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investigated a novel triple therapy combining osimertinib (a third-generation EGFR inhibitor), bevacizumab (an anti-VEGF antibody), and cetuximab (an anti-EGFR antibody) in EGFR-mutant non-small cell lung cancer (NSCLC) characterized by high expression of HIF-1 and TGF-

(2024) 10:e39684

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However, these protocols have limited success, and patients diagnosed with glioma have a dismal prognosis, with a median survival of 15 months and a 5-year survival rate of ~2%