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Kraen, M

cytotoxic, mutagenic and proinflammatory substances contained in cigarettes Surfactant smoking is associated with reduced surfactant phospholipids fibrotic factors T helper type 1 (Th1) cells are a lineage of CD4 + effector T cell that promotes cell-mediated immune responses and is required for host defense against intracellular viral and bacterial pathogens

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In epithelial cells and fibroblasts, CS induces the expression of the senescence markers p16, p19, and p21 in the development of emphysema [15]

Green was astonished by this failure