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Key areas of research have included wound healing and tissue repair, collagen and elastin synthesis in skin models, gene expression effects (the Connectivity Map studies), antioxidant mechanisms, and hair follicle stimulation (for AHK-Cu)

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Detection is performed using LC MS

Oxidative stress and inflammation are major contributors to premature skin aging, leading to the formation of fine lines, wrinkles, and uneven skin tone

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This typically includes measurement of IGF-1 and, where indicated, dynamic GH stimulation testing (such as an insulin tolerance test or glucagon stimulation test) and pituitary imaging