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Control of food intake by gastrointestinal peptides: mechanisms of action and possible modulation in the treatment of obesity

Nat Rev Drug Discov

In addition, five genes (HEY2, MSR1, MYOM3, COX17, and miRNA-24-1) were found to be hypermethylated in the ventricular septal tissues of heart failure patients that included hypertrophic obstructive cardiomyopathy, ischemic cardiomyopathy, and dilated cardiomyopathy

As discussed in our paper, glutamine uptake inhibitors not only activate the function of Teff cells in the TME, but also up-regulate the expression of PD-L1 in tumor cells, which may inhibit the function of Teff cells