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Laminin-5 and MMP upregulation TB4 induces expression of matrix metalloproteinases (MMP-2, MMP-9) that remodel extracellular matrix during healing (Malinda 1999 J Invest Dermatol)

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FOXO4-DRI and Neurological Function While the pathophysiology of certain neurological diseases remains unclear, it is presumed by researchers that there are changes in the proteasome enzyme activity over time, which may lead to cognitive impairment

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10.1111/j.1365-2125.2012.04172.x 3 DrmicD.KolencD.IlicS.BaukL.SeverM.Zenko SeverA.et al (2017)

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