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These results suggest that, in addition to leukotrienes, NT also inhibits the mRNA expression and as well as the production of the proinflammatory cytokine TNF- by mast cells i.e., both parameters of the late phase response

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In contrast, studies employing the chew and park method (as per the Nicorette gum use instructions), had C max values consistent with the results presented from this study 40,41,42

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