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Drugs that inhibit GABA breakdown or activate GABA receptors have been shown in animals to decrease the reinforcing effects of nicotine and prevent nicotine seeking behavior.12 C Cigarette smoking continues to result in signi cant morbidity and mortality in the United States

Risks We have synthesized peer-reviewed literature, toxicology databases, and traditional-use monographs to assess six commonly smoked herbs

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see also Gutierrez-Sigut et al., 2019 [Spanish] for ERP evidence)