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Description

Bulletin of Experimental Biology and Medicine

Cohorts in Part A treated with 0.03, 0.1, 0.3, and 0.5 mg/kg ImmTOR (in the absence of pegadricase) showed no change in sUA levels, as expected (blue symbols, Fig

The inability of DHODH for supporting VKD carboxylation could be due to DHODH being a mitochondrial inner membrane protein while VKD carboxylation occurs in the ER lumen