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Medical conditions that can cause pneumothorax include: Asthma Pneumonia COPD Collagen vascular disease Cystic fibrosis Emphysema Idiopathic pulmonary fibrosis Lung cancer Tuberculosis Acute respiratory disease syndrome (ARDS) Injuries that can cause lung include: Blunt force trauma Gunshot wounds Knife wounds Medical procedures that can cause your lung to collapse include: Nerve block Lung biopsy Central venous line placement Mechanical ventilation One-way valve therapy Lifestyle factors or activities that can cause pneumothorax or make it more likely include: Using drugs, especially if you inhale them Smoking Flying with big changes in air pressure Scuba diving or deep-sea diving Things that increase your risk of having a collapsed lung include: A family history of collapsed lung Pregnancy Being tall and thin, especially if you are a male or were assigned male at birth Marfan syndrome Endometriosis Often, someone who has a collapsed lung gets another one within 1 or 2 years