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Accompany with the report of ferroptosis, researchers found that many natural compounds, including dihydroisotanshinone I, 98,99 solasonine, 100 DMOCPTL, 101 cucurbitin B, 102 and honokiol 103 could induce ferroptosis by inhibiting GPX4 activity or reducing GPX4 protein level

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Front Immunol 13:831168 Nagappan A et al (2019) Cryptotanshinone from the Salvia miltiorrhiza Bunge attenuates ethanol-induced liver injury by activation of AMPK/SIRT1 and Nrf2 signaling pathways

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149 Furthermore, certain drugs like amitriptyline, commonly prescribed for depression, have been found to bind reversibly to the G-sites of GSTP1 and GSTA1, leading to a significant reduction in their activity