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By inhibiting autophagy/mitophagy with reduced optineurin, p62, TANK-binding kinase 1 phosphorylation, and PRKN expression, prolonged exposure of microglial cells to ssRNA40 amplified NLRP3 inflammasome activity, leading to increased inflammatory cytokine and ROS production and pyroptosis [46] (Fig

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Furthermore, glutathione biosynthesis is regulated by MfNAC in Medicago falcate , which controls the expression of glyoxalase-1 (GLO1) gene (Duan et al., 2017)

A glutathione-responsive sulfur dioxide polymer prodrug as a nanocarrier for combating drug-resistance in cancer chemotherapy

It can also cause stomach cramps, vomiting, and allergies like redness

Since glutathione is the main component in detoxification of hydroperoxides in mitochondria, its depletion in the brain is believed to promote mitochondrial insult most likely via increased ROS