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10.1038/sj.onc.1207521 41 GuanX.Ruo-shiL

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6 In addition, folic acid supplements can result in intakes above the tolerable upper intake level due to poor metabolism in the body

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The previously established xenograft PK/PD model, with the PK part replaced by the predicted human PK model, was used to simulate Met-EF1 modulation after M8891 dosing in humans