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The main biological difference is the absence of nicotine, which removes the vasoconstriction component but does not eliminate the pigmentation pathway

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1 2 "Impact of Smoking Cessation Duration on Exacerbation Readmission Frequency and Hospitalization Costs in COPD Beijing Municipality, China, 20132021"

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[ 18] Mucosal pigmentation It presents as diffuse or blotchy pigmentation on the under surface of the tongue, gums, or buccal mucosa