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'Why smoking impairs the ability to learn about safety is not clear, but one possibility is that smoking changes neurotransmitter balances in the brain, which are necessary for successful safety learning.' Dr Haaker and his colleagues now hope to unravel the mechanism underlying this effect with the hope of developing new treatments and perhaps even new drugs

NNN in particular is highly relevant to the health effects of cigars because it is a powerful oral cavity and esophageal carcinogen in rats when given in drinking water, while a mixture of NNN and NNK also produced oral and lung cancers in rats when applied in the oral cavity (Balbo et al., 2013

doi:10.1038/s41598-025-00458-9 57

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