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A chemical with a median lethal concentration (LC50) in air of 200 parts per million (ppm) by volume or less of gas or vapor, or 2 mg per liter or less of mist, fume, or dust, when administered to certain test populations (e.g., albino rats weighing between 200 and 300 gm each) by continuous inhalation for one hour, provided such concentration and/or condition are likely to be encountered by humans when the chemical is used in any reasonably foreseeable manner

SASP induction by senescent cancer cells can also improve tumor vascularization, a phenomenon that may be considered beneficial, as demonstrated in previous studies on PDAC cells [39]

Nature 476 (7360), 346350

Nonetheless, caution should be taken when interpreting results from studies with identified methodological limitations

291 , C218C230 (2006)

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