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Phytochemistry 26:24892491 Hussain MI, Qamar Abbas S, Reigosa MJ (2017) Activities and novel applications of secondary metabolite coumarins

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oxidase, hydrolase, lipase, synthetase, dehydrogenase, etc Blood CNS Muscles Heart Metabolism may result in: Pharmacologically inactive drug (detoxification)

302 PEO can be classified into three phenotypes: pure PEO (isolated occurrence), Kearns-Sayre syndrome, and PEO-plus syndrome, where myopathy or other extraocular symptoms are present