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Generally, growth is genetically regulated and affected by cellular, endocrinological and environmental factors in which the endocrinal tissues are affected by the integration of external stimuli and internal signal based on physiological status 97

Liu S, Cheng S, Chen B, Xiao P, Zhan J, Liu J, et al

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GTPases then require the help of GAPs to hydrolyze GTP and switch off the signaling cascade