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Lack of ACTH reduces the production of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in the adrenal glands in both men and women, leading to lower testosterone levels in both sexes (173, 174)

R., de Lucia C., TovarRios D

These risks may be amplified in older patients due to underlying immune dysregulation associated with inflammaging. Implementing rigorous safety protocols, adapted from oncology, such as careful dose escalation and monitoring for autoantibodies, will be essential to ensure patient safety 118,119

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Cell Signal 18 , 401408 (2006)