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Moreover, the intricate composition of the bioactive molecules, coupled with their ability to traverse cellular barriers and penetrate various tissues, renders them highly suitable for a wide range of biomedical applications

These efforts must be combined with the generation of in vivo and in vitro models to validate molecular targets identified from omics analyses of marine-species

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For instance, the degree of immune cell infiltration and the activity of cancer-associated fibroblasts (CAFs) demonstrate significant variations among subtypes, which may potentially impact treatment efficacy and patient prognosis ( Therefore, understanding the clinical manifestations and biological characteristics of various subtypes is essential for developing effective treatment strategies

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