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An open-label phase II study of F-652 showed significant improvement in MELD scores for 18 patients by day 4 [259]

520 This should enable the newly vacated codons to be reassigned for ncAAs

Arora R, Nimonkar AV, Baird D, Wang C, Chiu CH, Horton PA, Hanrahan S, Cubbon R, Weldon S, Tschantz WR, Mueller S, Brunner R, Lehr P, Meier P, Ottl J, Voznesensky A, Pandey P, Smith TM, Stojanovic A, Flyer A, Benson TE, Romanowski MJ, Trauger JW (2019) Structure of lipoprotein lipase in complex with GPIHBP1