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Notably, the enzymatic activity of GPX4 is strictly dependent on its active-site selenocysteine residue (168), implying that dietary selenium intake directly regulates GPX4 protein expression and functional activity, thereby determining cellular susceptibility to ferroptosis

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and was cultured in McCoys 5 A medium (GBICO, CA, USA)

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Therefore, beta-blockers cause decreases in heart rate, contractility, conduction velocity, and relaxation rate