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Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1alpha inhibition in hepatocellular carcinoma

doi: 10.1152/physrev.1999.79.4.1431

As critical endogenous mediators, gas signaling moleculesincluding nitric oxide (NO), hydrogen sulfide (H 2 S), and hydrogen (H 2 )facilitate cellular communication and maintain physiological homeostasis

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Functional analysis of the DEGs revealed that, in addition to metabolism, other functions such as development, cell communication, signal transduction and cell differentiation were associated with these DEGs, highlighting their involvement and influence on hepatocyte differentiation