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Sold in combination with Electronic cigarettes are sold in combination with nicotine when: Any of the items are sold with any nicotine liquid or substance in their original manufacturer packaging as one unit, or Sold for a single price before or when the nicotine liquid or substance is distributed

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95,96 For example, in issuing Not Substantially Equivalent Orders prohibiting the sale of certain cigarette sub-brands, the FDA noted that differences in sugar levels contributed its decision because the effects on the products palatability, abuse liability, and use behaviors, 97 as well as the mainstream smoke yields of toxicants

Smoking may have a more pronounced effect on crossing a clinical disease threshold than on shifting population-wide BP levels