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Interestingly, pretreatment of the resistant (vemurafenib and CTL) clones with HDACi (suberoylanidilide hydroxamic acid, SAHA) for 48 hours reversed their resistance to F5 CTL and NK-killing, but not to BRAFi

Supports Extracellular Matrix Remodeling The extracellular matrix (ECM) provides structural and biochemical support to surrounding cells

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Future Perspectives and Challenges Ferroptosis was initially discovered as a novel form of RCD in 2012, and its underlying transduction mechanisms have recently gained increasing attention in cancer research ( , GPX4, FSP1 and BH1), various ferroptosis inducers and techniques have been discovered and potentially applied in cancer treatment (Figure 7)

CD000232 Riley GP (2004) Tendon and ligament biochemistry and pathology