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Collagen, a pivotal biomarker for organismal skin aging, was assessed via quantification of its hallmark component, HYP

452 Targeted drug delivery Targeted drug delivery is a strategic approach in drug administration that aims to deliver therapeutic agents precisely to specific tissues or sites, thereby enhancing therapeutic efficacy while minimizing adverse reactions

Additionally, Ca 2+ involvement and the highly active mitochondrial oxidative phosphorylation processes in astrocytes and oligodendrocytes facilitate the substantial release of ROS

reported that in a rat model of hepatic I/R injury, the depletion of Nrf2 aggravated inflammation and lead to oxidative stress and apoptosis 30

Additionally, C75 induces apoptosis across various cancer cell lines, suggesting its potential as a therapeutic target for cancer (71)

While the spheroids treated with Ru(II)-OH or NP2 in a 1% O 2 atmosphere majorly consisted of living cells, the spheroids treated with NP4 in a 1% O 2 atmosphere consisted of dead cells (Fig