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Liu X, Zhang X, Zhu M, Lin G, Liu J, Zhou Z, et al

8 CUL5 and angiogenesis CUL5 exerts critical control over tumor angiogenesis by ubiquitinating and modulating key signaling pathways, including TRAF6, HIF, and MAPK

It helps protect neurons from damage caused by free radicals and other harmful substances

The anti-colitis effect of Schisandra chinensis polysaccharide is associated with the regulation of the composition and metabolism of gut microbiota

Notably, NO can also be synthesized through non-enzymatic pathways, particularly under hypoxic conditions (18)

These results underscore the pivotal role of the epitranscriptome in governing iPSC fate and accentuate the potential utilization of epitranscriptomic modifications as targets for enhancing iPSC-based therapies