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Six were depleted in the frail brain, including cytoskeletal proteoforms derived from MAP2, -tubulin and vimentin, whilst 16 were increased with cognitive frailty, including CHGA/B, CCK and other cytoskeletal peptides such as -tubulin and PALM (Fig

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Quantitative real-time PCR analysis revealed a significant age-dependent downregulation of HDAC9 mRNA expression in both the PFC and hippocampus (Fig