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Chen, Y., Merzdorf, C., Paul, D

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The mechanism appears to involve tyrosinase activity, oxidative stress, and toxic metabolites that place melanocytes under severe pressure

These observations indicate that nanoformulations of ibuprofen or other NSAIDs can increase effectivity within the brain and at the same time minimalize the adverse peripheral side-effects [79]

Elevated intracellular sorbitol also provides excess nicotinamide adenine dinucleotide (NADH) to the mitochondrial electron transport chain, which is a substrate for complex I (substrate for complex I) in mitochondria and closely affects mitochondrial function and cellular energy metabolism