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The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction

Expression profiles are redirected toward signatures characteristic of younger tissues

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Finally, the European Medicines Agency (EMA) safety committee Pharmacovigilance Risk Assessment Committee (PRAC) has completed its review of medicines containing semaglutide

Disclosure of interest: Lupei Cai: nothing to disclose

Western Blot Total proteins were extracted in RIPA buffer (Sigma-Aldrich) that was supplemented with protease inhibitor cocktail (100 Sigma-Aldrich)