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Regarding gut-liver axis, several studies have indeed established that the trigger that causes systemic/liver inflammation to exacerbate liver injury (211) is prevented by betaine through stabilizing TJs between enterocytes and preventing the translocation of harmful gut-derived toxins/pathogens to the liver (34, 35, 202, 203)

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Other protein that may be involved in the inflammatory response and LD formation is the cell death-inducing DFF45-like effector b (Cideb)