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Ride is the first known LGBT astronaut

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Shatner had his reservations and, although he attended events and collected substantial fees for autographs, speeches and participation in question-and-answer panels for many years, his apparent disdain for the events and the fans themselves became so well known that, years later, he actually did a now-infamous skit on "Saturday Night Live," in which he told a roomful of adoring Trekkies to "get a life!" The phrase, and the sentiment behind it, caused immediate outrage from the fans and former cast mates, not to mention a movie studio that was investing tens of millions of dollars into each Star Trek movie installment

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One of the main reasons is the response of a host plants metal cross-homeostasis network to changes generated by the activity of a foreign protein that alters the status of metals in cells and tissues

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