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Metformin is recommended as the first-line treatment for type 2 DM, as it can improve endothelial dysfunction by enhancing endothelium-dependent vasodilation and reducing sympathetic overactivity, ultimately restoring erectile responses in the CC of DM animal models through the NO/cGMP pathway [168]

Therefore, although numerous small molecule drugs have been discovered for inducing and inhibiting ferroptosis, these drugs have not yet been translated into clinical applications to benefit patients

These motifs contain conserved amino acid residues that are critical for catalyzing RNA synthesis

S., Paredes-Gonzalez X., Fuentes F., et al

doi: 10.1093/annonc/mdx184 35 CostaGPOFerreira-FilhoESSimoesRDSSoares-JuniorJMBaracatECMacielGARet al

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