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Cysteine constitutes the rate-limiting precursor for glutathione (GSH) synthesis, particularly active in the liver and crucial in protecting cells by neutralizing reactive oxygen species (ROS), detoxifying xenobiotics and even regulating protein functions through S-glutathionylation [48]

39 Of note, the authors did treat the patient with ursodeoxycholic acid 600 mg/day for close to a year

INSR, insulin receptor

Animal models, while more physiologically complex, are expensive, ethically constrained, and often poorly predictive of human pathophysiology, contributing to translational failure (56)

Mechanistically, chromatin immunoprecipitation (ChIP) and dual luciferase reporter gene assays were used to confirm that signal transducer and activator of transcription 3 (STAT3) binds to the GPX4 promoter region and promotes its transcription, whereas TST blocked GPX4 expression by regulating STAT3

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