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doi: 10.1080/21691401.2017.1394872 305 YesiltepeM.MetkarS.YinT.ChakrabortyI.D'AdamioL

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The compound's ability to restore tissue homeostasis and reverse age-related functional decline in animal models provides direct evidence for the role of senescent cells in aging processes, while its applications in cancer research offer insights into senescence mechanisms in disease progression and administration resistance

Rather than sedating, it appears to normalize disrupted sleep architecture in animal and small human studies

15,18 These epigenetic alterations lead to metabolic dysregulation, cartilage degradation, and joint dysfunction (Figure 1)

When combined with appropriate testosterone optimization, IGF-1 can amplify the benefits of both therapies