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The prevailing view of targeted protein degradation is that a properly designed PROTAC induces the formation of the neosubstratePROTACE3 ternary complex and that the neosubstrate is readily ubiquitylated and degraded through harnessing the conventional proteasomal pathway 2

This is why proper screening is mandatory before starting therapy

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Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis - manipulation by the electromagnetic field

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